Article

Cell state and transcription factor modulation during extended ex vivo CD8 <sup>+</sup> T-cell expansion

2024-07-22

Abstract excerpt

Adoptive cell therapy is becoming a cornerstone of tumour immunotherapy. It relies on the relatively long-term (> 2 week) ex vivo expansion of T cells either in the form of tumour-infiltrating cells, or bulk cells modified with the expression of heterologous signalling proteins, e.g., chimeric antigen receptors. However, relatively little is known about the developmental trajectories of T cells under these conditi...

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Literature Corpus work: 409b4759-706f-5e03-ae88-a1f99b584b7f
DOI: 10.1101/2024.07.17.603780

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