Article

TCR activation impairs CAR-T cytotoxicity against separate target cells

2025-10-07

Abstract excerpt

Chimeric antigen receptor T cells (CAR-T) are effective therapeutics against cancer and autoimmunity, but whether the endogenous T-cell receptor (TCR) is beneficial, detrimental or irrelevant for CAR-T function and patient outcome remains unclear. We here traced anti-CD19 CAR-T clonotypes in patients with B-cell malignancies pre- and post-infusion using single-cell RNA-, TCR-, and CITE-sequencing. A cytotoxic phen...

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Literature Corpus work: cc581182-d063-52b9-ae10-f5cf68714dd5
DOI: 10.1101/2025.10.07.680634

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