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Mapping the evolution of T cell states during response and resistance to adoptive cellular therapy

1 Nov 2021

Abstract excerpt

To elucidate mechanisms by which T cells eliminate leukemia, we study donor lymphocyte infusion (DLI), an established immunotherapy for relapsed leukemia. We model T cell dynamics by integrating longitudinal, multimodal data from 94,517 bone marrow-derived single T cell transcriptomes in addition to chromatin accessibility and single T cell receptor sequencing from patients undergoing DLI. We find that responsive...

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PMID: 34758319
DOI: 10.1016/j.celrep.2021.109992

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