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Article

Identification and selective expansion of functionally superior T cells expressing chimeric antigen receptors.

Journal of translational medicine - 20 May 2015

Chang ZeNan L, Silver Pamela A, Chen Yvonne Y

Abstract excerpt

BACKGROUND: T cells expressing chimeric antigen receptors (CARs) have shown exciting promise in cancer therapy, particularly in the treatment of B-cell malignancies. However, optimization of CAR-T cell production remains a trial-and-error exercise due to a lack of phenotypic benchmarks that are clearly predictive of anti-tumor functionality. A close examination of the dynamic changes experienced by CAR-T cells...

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Identifiers

PMID: 25990251
DOI: 10.1186/s12967-015-0519-8
PMCID: PMC4457995

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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