Article

Single-cell genomics links CAR architectures to in vivo effector chromatin states in T cells responding to antigen-low leukemia

2026-06-29

Abstract excerpt

<title>Abstract</title> <p>Chimeric antigen receptor (CAR) T cells produce extraordinary remission rates in some hematologic malignancies, but relapses occur, often through antigen-low tumor escape. Clinical efficacy against antigen-low cancers is enhanced by modifying CAR architecture, with a drastic effect observed in CD22-CAR T cells. However, efforts to define biology driving CAR T cell responses to antigen-l...

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Literature Corpus work: 1040f7aa-4873-5314-a6f3-347fea1a70b7
DOI: 10.21203/rs.3.rs-9859689/v1

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