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Article

Functional diversification and dynamics of CAR-T cells in patients with B-ALL

1 Oct 2023

Abstract excerpt

Understanding of cellular evolution and molecular programs of chimeric antigen receptor-engineered (CAR)-T cells post-infusion is pivotal for developing better treatment strategies. Here, we construct a longitudinal high-precision single-cell transcriptomic landscape of 7,578 CAR-T cells from 26 patients with B cell acute lymphoblastic leukemia (B-ALL) post-infusion. We molecularly identify eight CAR-T cell...

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PMID: 37851569
DOI: 10.1016/j.celrep.2023.113263

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