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Engineering better chimeric antigen receptor T cells

1 Dec 2020

Abstract excerpt

CD19-targeted CAR T cells therapy has shown remarkable efficacy in treatment of B cell malignancies. However, relapse of primary disease remains a major obstacle after CAR T cells therapy, and the majority of relapses present a tumor phenotype with retention of target antigen (antigen-positive relapse), which highly correlate with poor CAR T cells persistence. Therefore, study on factors and mechanisms that limit...

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PMID: 33292660
DOI: 10.1186/s40164-020-00190-2

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