Article

<i>NF1</i> deficiency drives metabolic reprogramming in ER+ breast cancer

2023-11-25

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> NF1 is a tumor suppressor gene and its protein product, neurofibromin, is the key negative regulator of the RAS pathway. NF1 is one of the top driver mutations in sporadic breast cancer such that 27% of breast cancers exhibit damaging NF1 alterations. NF1 loss-of-function is a frequent event in the genomic evolution of estrogen receptor (ER)+ breast cancer metastasis and e...

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Literature Corpus work: 8fa636c6-c38a-5811-96fc-b89d756cd909
DOI: 10.1101/2023.11.24.568339

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