Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Oncogenes induce the cancer-associated fibroblast phenotype: metabolic symbiosis and "fibroblast addiction" are new therapeutic targets for drug discovery.

Cell cycle (Georgetown, Tex.) - 1 Sept 2013

Lisanti Michael P, Martinez-Outschoorn Ubaldo E, Sotgia Federica

Abstract excerpt

Metabolic coupling, between mitochondria in cancer cells and catabolism in stromal fibroblasts, promotes tumor growth, recurrence, metastasis, and predicts anticancer drug resistance. Catabolic fibroblasts donate the necessary fuels (such as L-lactate, ketones, glutamine, other amino acids, and fatty acids) to anabolic cancer cells, to metabolize via their TCA cycle and oxidative phosphorylation (OXPHOS). This...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diet and metabolism studies
Share to Drug Discovery

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblasts

Share to BRCA1 gene

Share to Molecular Targeted Therapy

Share to Neoplasms

Share to Oncogenes

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 23860382
DOI: 10.4161/cc.25695
PMCID: PMC3899185

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oncogenes induce the cancer-associated fibroblast phenotype: metabolic symbiosis and "fibroblast addiction" are new therapeutic targets for drug discovery.PMID 23860382Read ↗

Metabolic reprogramming of carcinoma-associated fibroblasts and its impact on metabolic heterogeneity of tumors.Semantic proximity Read ↗

Unraveling the intricacies of cancer‐associated fibroblasts: a comprehensive review on metabolic reprogramming and tumor microenvironment crosstalkSemantic proximity Read ↗

Understanding the "lethal" drivers of tumor-stroma co-evolutionSemantic proximity Read ↗

The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stromaSemantic proximity Read ↗

Bridging the tumor microenvironment: the pivotal role of cancer-associated fibroblasts in tumor cachexia developmentSemantic proximity Read ↗

Tumor microenvironment and metabolic synergy in breast cancers: critical importance of mitochondrial fuels and function.Semantic proximity Read ↗

The Engaged Role of Tumor Microenvironment in Cancer Metabolism: Focusing on Cancer-Associated Fibroblast and Exosome MediatorsSemantic proximity Read ↗

Cancer-associated fibroblasts as abettors of tumor progression at the crossroads of EMT and therapy resistanceSemantic proximity Read ↗

Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for TherapySemantic proximity Read ↗

Cigarette smoke metabolically promotes cancer, via autophagy and premature aging in the host stromal microenvironmentSemantic proximity Read ↗

Metabolic reprogramming: a bridge between aging and tumorigenesisSemantic proximity Read ↗

Cancer Cell Metabolism Reprogramming and Its Potential Implications on Therapy in Squamous Cell Carcinoma of the Head and Neck: A ReviewSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.