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Article

NF1 deficiency drives metabolic reprogramming in ER+ breast cancer

10 Jan 2024

Abstract excerpt

NF1 is a tumor suppressor gene and its protein product, neurofibromin, is a negative regulator of the RAS pathway. NF1 is one of the top driver mutations in sporadic breast cancer such that 27% of breast cancers exhibit damaging NF1 alterations. NF1 loss-of-function is a frequent event in the genomic evolution of estrogen receptor (ER)+ breast cancer metastasis and endocrine resistance. Individuals with...

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Identifiers

PMID: 38216123
DOI: 10.1016/j.molmet.2024.101876

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