Article

NF1 deficiency induces metabolic reprogramming and epithelial-mesenchymal transition in glioblastoma

2026-06-19

Abstract excerpt

<h4>Background</h4> Metabolic reprogramming is a common occurrence in tumor cells, where enhanced glycolysis promotes cell growth, invasion and migration. NF1 is tumor suppressor gene that downregulates the encoded neurofibromin protein. However, the effects of NF1 on energy metabolism and epithelial-mesenchymal transition (EMT) in glioblastoma multiforme (GBM), as well as the underlying molecular mechanisms, rem...

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Literature Corpus work: b5d145c0-457f-52d9-a147-e7d5011634d1
DOI: 10.64898/2026.06.17.733017

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