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NF1 deficiency correlates with estrogen receptor signaling and diminished survival in breast cancer

24 Aug 2018

Abstract excerpt

Abstract The key negative regulatory gene of the RAS pathway, NF1 , is mutated or deleted in numerous cancer types and is associated with increased cancer risk and drug resistance. Even though women with neurofibromatosis (germline NF1 mutations) have a substantially increased breast cancer risk at a young age and NF1 is commonly mutated in sporadic breast cancers, we have a limited understanding of the role of...

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PMID: 30182054
DOI: 10.1038/s41523-018-0080-8

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