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Characterizing neurofibromin 1-altered breast cancer through genomic, functional, and clinical analyses.

Virchows Archiv : an international journal of pathology - 1 Aug 2026

Mao Xueyan, Ma Kang, Wang Yunjie, Long Cheng, Tan Xuejing, Chen Xi, Chen Bo

Abstract excerpt

Breast cancer is a leading cause of cancer-related morbidity and mortality among women worldwide, with increasing incidence in China. The neurofibromatosis type 1 (NF1) gene, a critical tumor suppressor regulating the Ras/MAPK pathway, has been implicated in aggressive breast cancer phenotypes, yet its somatic alterations in Asian populations remain poorly characterized. This study integrates genomic,...

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Biomarkers, Tumor
Breast Neoplasms
NF1 gene
PIK3CA gene
TP53 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neurofibromin 1

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Identifiers

PMID: 40804585
DOI: 10.1007/s00428-025-04218-y

Genes

NF1
PIK3CA
TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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