Article

<i>NF1</i> deficiency correlates with estrogen receptor signaling and diminished survival in breast cancer

2018-02-27

Abstract excerpt

The key negative regulatory gene of the RAS pathway, NF1 , is mutated or deleted in numerous cancer types and is associated with increased cancer risk and drug resistance. Even though women with neurofibromatosis (germline NF1 mutations) have a substantially increased breast cancer risk at a young age and NF1 is commonly mutated in sporadic breast cancers, we have a limited understanding of the role of NF1 in...

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Literature Corpus work: 4e875cc1-ec73-5467-9ba5-4e8e80aa86f7
DOI: 10.1101/272815

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