Article

<i>Nf1</i> Deficiency Increases Mammary Collagen Deposition and Restricts Adipocyte Differentiation Before Tumor Formation

2023-06-01

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Neurofibromin, coded by the NF1 tumor suppressor gene, is the main negative regulator of the RAS pathway and is frequently mutated in various cancers. Women with Neurofibromatosis Type I (NF1) – a tumor predisposition syndrome caused by a germline NF1 mutation – have an increased risk of developing aggressive breast cancer with poorer prognosis. The mechanism by which NF1...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4b1a371f-46b7-531b-839d-a4df15d56081
DOI: 10.1101/2023.06.01.539442

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>Nf1</i> Deficiency Increases Mammary Collagen Deposition and Restricts Adipocyte Differentiation Before Tumor FormationDOI 10.1101/2023.06.01.539442Read

Emerging therapeutic targets for neurofibromatosis type 1Semantic proximity Read

Characterizing neurofibromin 1-altered breast cancer through genomic, functional, and clinical analyses.Semantic proximity Read

<i>NF1</i> deficiency correlates with estrogen receptor signaling and diminished survival in breast cancerSemantic proximity Read

Single-Cell Analysis of <i>NF1</i> -Expressing and <i>NF1</i> -Deficient Schwann and Fibroblast Cells Reveals Divergent Neurofibroma ProgramsSemantic proximity Read

Molecular, genetic, and cellular pathogenesis of neurofibromas and surgical implications.Semantic proximity Read

Neurofibromatosis Type 1: Pathology, Clinical Features and Molecular GeneticsSemantic proximity Read

Dissecting Clinical Heterogeneity in Neurofibromatosis Type 1Semantic proximity Read

The NF1+/- Immune Microenvironment: Dueling Roles in Neurofibroma Development and Malignant TransformationSemantic proximity Read

NF1 deficiency correlates with estrogen receptor signaling and diminished survival in breast cancerSemantic proximity Read

NeurofibromatosisSemantic proximity Read

TGFβ-dependent signaling drives tumor growth and aberrant extracellular matrix dynamics in NF1-associated plexiform neurofibromaSemantic proximity Read

NFKB1 as a key player in Tumor biology: from mechanisms to therapeutic implications.Semantic proximity Read