Article

Epithelial state-transitions permit inflammation-induced tumorigenesis

2025-06-27

Abstract excerpt

Chronic inflammation across tissues is associated with an increased risk of developing cancer 1–3 . While potentially oncogenic somatic mutations have been demonstrated to persist and expand in healthy organs 4–6 , what triggers a subset of cells harbouring deleterious mutations to transition into a neoplasm or an aggressive adenoma with poor prognosis 7,8 is not well-understood. Unlike normal, healthy cells, b...

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Literature Corpus work: 13682a74-90c5-56b7-834e-6ecde9eacb30
DOI: 10.1101/2025.06.22.660911

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