Article

Fluorescent peptomer substrates for differential degradation by metalloproteases

2022-09-02

Abstract excerpt

Proteases, especially MMPs, are attractive biomarkers given their central role in both physiological and pathological processes. Distinguishing MMP activity with degradable substrates, however, is a difficult task due to overlapping substrate specificity profiles. Here, we developed a system of peptomers (peptide-peptoid hybrids) to probe the impact of non-natural residues on MMP specificity for a MMP peptide cons...

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Literature Corpus work: 8f75293f-ee0e-5034-a43a-a8569ba41d7b
DOI: 10.1101/2022.08.31.506126

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