Article

Deep learning guided design of protease substrates

2025-03-02

Abstract excerpt

Proteases, a class of enzymes that play critical roles in health and disease, exert their function through the cleavage of peptide bonds. Identifying substrates that are efficiently and selectively cleaved by target proteases is essential for studying protease activity and for harnessing their activity in protease-activated diagnostics and therapeutics. However, the vast design space of possible substrates (c.a. 2...

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Literature Corpus work: 2e22154f-e40d-5322-83d5-816c125a5e0b
DOI: 10.1101/2025.02.27.640681

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