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Article

Non-destructive and selective imaging of the functionally active, pro-invasive membrane type-1 matrix metalloproteinase (MT1-MMP) enzyme in cancer cells.

The Journal of biological chemistry - 12 Jul 2013

Remacle Albert G, Shiryaev Sergey A, Golubkov Vladislav S, Freskos John N, Brown Michael A, Karwa Amolkumar S, Naik Arati D, Howard Carol P, Sympson Carolyn J, Strongin Alex Y

Abstract excerpt

Proteolytic activity of cell surface-associated MT1-matrix metalloproteinase (MMP) (MMP-14) is directly related to cell migration, invasion, and metastasis. MT1-MMP is regulated as a proteinase by activation and conversion of the latent proenzyme into the active enzyme, and also via inhibition by...

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Identifiers

PMID: 23733191
DOI: 10.1074/jbc.M113.471508
PMCID: PMC3711321

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23733191-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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