Peptide Backbone Composition and Protease Susceptibility: Impact of Modification Type, Position, and Tandem Substitution

Abstract excerpt

The clinical utility of peptides is limited by their rapid degradation by endogenous proteases. Modification of the peptide backbone can generate functional analogues with enhanced proteolytic stability. Existing principles for the design of such oligomers have focused primarily on effective structural mimicry. A more robust strategy would incorporate a rational approach for engineering maximal proteolytic...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Biochemical and Structural Characterization
• Share to Chemical Synthesis and Analysis
• Share to Peptidase Inhibition and Analysis