Solid-Phase Synthesis of ProTide Fluorogenic Probes Enables Systematic Profiling of Carboxypeptidase Activity

Abstract excerpt

<h4>ABSTRACT</h4> Carboxypeptidases play diverse roles in physiological and pathological processes, yet comprehensive analysis of their activities in complex biological samples remains challenging. Here we report a solid-phase synthesis strategy for fluorogenic ProTide-based probes that enables systematic profiling of carboxypeptidase activities based on defined C-terminal amino acid motifs. By modular synthesis...

Topics

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• Cellular transport and secretion
• Click Chemistry and Applications
• Coagulation, Bradykinin, Polyphosphates, and Angioedema
• Machine Learning in Bioinformatics
• Peptidase Inhibition and Analysis
• Protein Degradation and Inhibitors
• Streptococcal Infections and Treatments
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

0eaa0e54-1bff-55c0-8790-626a70a2f153

DOI

10.64898/2026.03.10.710453