Article

Engineering cathepsin S selective chemical probes and antibody-drug conjugates through substrate profiling with unnatural amino acids

2025-12-23

Abstract excerpt

Cysteine cathepsins, particularly cathepsin S, are important regulators of proteolytic signaling in health and disease, including cancer progression and immune modulation. Despite their therapeutic relevance, selective chemical tools to study individual cathepsins remain limited due to overlapping substrate preferences. Here we present design of cathepsin S selective chemical probes and cathepsin S-cleavable antib...

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Literature Corpus work: 2f2b8738-19ce-5a80-ae65-cd6b8169e7de
DOI: 10.64898/2025.12.20.695745

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