Article

Integrated Analysis of Somatic DNA Variants and DNA Methylation of Tumor Suppressor Genes in Colorectal Cancer

2025-01-07

Abstract excerpt

DNA methylation of tumor suppressor genes in cancer is known to be a mechanism for silencing gene expression, but much remains unknown about its extent, degree, and rela-tionship to somatic variants at the DNA sequence level. In this study, we comprehensively analyzed DNA methylation and somatic variants of all gene regions across the genome of the major tumor suppressor genes, APC, TP53, SMAD4, and mismatch repai...

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Literature Corpus work: 8f6ef5cb-15c2-5243-967e-00a368a872ad
DOI: 10.20944/preprints202501.0537.v1

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