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Article

Somatic mutations in colorectal cancer are associated with the epigenetic modifications.

Journal of cellular and molecular medicine - 1 Oct 2020

Lei Hongwei, Tao Kaixiong

Abstract excerpt

Colorectal cancer (CRC) mostly arises from progressive accumulation of somatic mutations within cells. Most commonly mutated genes like TP53, APC and KRAS can promote survival and proliferation of cancer cells. Although the molecular alterations and landscape of some specific mutations in CRC are well known, the presence of a somatic mutation signature related to genomic regions and epigenetic markers remain...

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PMID: 32865336
DOI: 10.1111/jcmm.15799
PMCID: PMC7579689

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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