Article

Comparing the DNA Hypermethylome with Gene Mutations in Human Colorectal Cancer

2005-01-01

Abstract excerpt

We have developed a transcriptome-wide approach to identify genes affected by promoter CpG island DNA hypermethylation and transcriptional silencing in colorectal cancer.By screening cell lines and validating tumorspecific hypermethylation in a panel of primary human colorectal cancer samples, we estimate that nearly 5% or more of all known genes may be promoter methylated in an individual tumor.When directly comp...

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Genetic factors in colorectal cancer

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Literature Corpus work: 8e089d8c-5998-5cae-bb7b-ff682f5e8f03
DOI: 10.1371/journal.pgen.0030157.eor

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