Article
The epigenetics of colorectal cancer.
Annals of the New York Academy of Sciences - 1 Jun 2000
Issa J P
Abstract excerpt
Colorectal cancer has provided an excellent model for studying the genetic basis of cancer and is one of the better-understood malignancies in this regard. The orderly progression of the disease, with distinct genetic alterations at each step, is a useful framework for deciphering the molecular basis of neoplasia. Epigenetics, the study of clonal changes in gene expression without associated genetic lesions, has...
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