Article
Comparing the DNA hypermethylome with gene mutations in human colorectal cancer.
PLoS genetics - 1 Sept 2007
Schuebel Kornel E, Chen Wei, Cope Leslie, Glöckner Sabine C, Suzuki Hiromu, Yi Joo-Mi, Chan Timothy A, Van Neste Leander, Van Criekinge Wim, van den Bosch Sandra, van Engeland Manon, Ting Angela H, Jair Kamwing, Yu Wayne, Toyota Minoru, Imai Kohzoh, Ahuja Nita, Herman James G, Baylin Stephen B
Abstract excerpt
We have developed a transcriptome-wide approach to identify genes affected by promoter CpG island DNA hypermethylation and transcriptional silencing in colorectal cancer. By screening cell lines and validating tumor-specific hypermethylation in a panel of primary human colorectal cancer samples, we estimate that nearly 5% or more of all known genes may be promoter methylated in an individual tumor. When directly...
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