Article

Epigenetic Changes Associated with the Progression of Prion Disease in Syrian Hamsters (Mesocricetus auratus)

2025-10-21

Abstract excerpt

<title>Abstract</title> <p>Prion diseases are fatal neurodegenerative disorders that affect mammals, including Creutzfeldt-Jakob disease in humans, chronic wasting disease in cervids, and bovine spongiform encephalopathy in cattle. During the disease, abnormally folded prion proteins induce misfolding of normal prion proteins, leading to neurotoxic fibrils and plaques. Epigenetic mechanisms, particularly DNA meth...

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Literature Corpus work: 8f46df39-9906-561f-8efc-6d47a350468d
DOI: 10.21203/rs.3.rs-7850591/v1

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