Article

Genome-wide transcriptomics identifies an early preclinical signature of prion infection

2020-01-11

Abstract excerpt

The clinical course of prion diseases is accurately predictable despite long latency periods, suggesting that prion pathogenesis is driven by precisely timed molecular events. We constructed a searchable genome-wide atlas of mRNA abundance, splicing and editing alterations during the course of disease in prion-inoculated mice. Prion infection induced transient changes in mRNA abundance and processing already at ei...

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Literature Corpus work: cf1f52b5-d32e-55e2-89fd-3a7c441f0b83
DOI: 10.1101/2020.01.10.901637

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