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Zinc Finger Repressors mediate widespread <i>PRNP</i> lowering in the nonhuman primate brain and profoundly extend survival in prion disease mice

2025-03-10

Abstract excerpt

Prion disease is a rapidly progressing and invariably fatal neurodegenerative disorder with no approved treatment. The disease is caused by the self-templated misfolding of the prion protein (PrP) into toxic species, ultimately leading to neurodegeneration and death. We evaluated a novel epigenetic regulation approach using Zinc Finger Repressors (ZFRs) to ablate PrP expression at the transcriptional level. When d...

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Identifiers and source

Literature Corpus work
ef074be5-a9ab-5cd9-8a79-88bb46383a54
DOI
10.1101/2025.03.05.636713
Open publication

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Zinc Finger Repressors mediate widespread <i>PRNP</i> lowering in the nonhuman primate brain and profoundly extend survival in prion disease miceDOI 10.1101/2025.03.05.636713
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