Article

Single-nuclei transcriptomics of mammalian prion diseases identifies dynamic gene signatures shared between species

2022-09-15

Abstract excerpt

<h4>ABSTRACT</h4> Mammalian prion diseases are fatal and transmissible neurological conditions caused by the propagation of prions, self-replicating multimeric assemblies of misfolded forms of host cellular prion protein (PrP). The most common human form of the disease, sporadic Creutzfeldt-Jakob disease (sCJD), typically presents as a rapidly progressive dementia and has no effective treatments. Prion diseases a...

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Literature Corpus work: cf3515db-21b2-5970-bb97-32e7f3316f31
DOI: 10.1101/2022.09.13.507650

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