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Targeting the epigenome to treat neurodegenerative diseases or delay their onset: a perspective

10 Dec 2021

Abstract excerpt

Epigenetic mechanisms regulate the chromatin structure and gene expression levels without changing the primary DNA sequence, and include DNA methylation and hydroxymethylation, post-translational modifications of histone tails and nucleosome positioning, as well as mechanisms mediated by long and short non-coding RNA molecules. These mechanisms are required for human development and cell differentiation, and are...

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PMID: 35017429
DOI: 10.4103/1673-5374.332145

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