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Multiomic analyses direct hypotheses for Creutzfeldt-Jakob disease risk genes

24 Jan 2025

Abstract excerpt

Prions are assemblies of misfolded prion protein that cause several fatal and transmissible neurodegenerative diseases, with the most common phenotype in humans being sporadic Creutzfeldt-Jakob disease (sCJD). Aside from variation of the prion protein itself, molecular risk factors are not well understood. Prion and prion-like mechanisms are thought to underpin common neurodegenerative disorders meaning that the...

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Folate and B Vitamins Research
Neurological diseases and metabolism
Prion Diseases and Protein Misfolding

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PMID: 39865733
DOI: 10.1093/brain/awaf032

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