Article

TF protein of Sindbis virus antagonizes host type I interferon responses in a palmitoylation-dependent manner

2019-12-13

Abstract excerpt

Sindbis virus (SINV) produces the small membrane protein TF from the 6K gene via a (−1) programmed ribosomal frameshifting. While several groups have shown that TF-deficient virus exhibits reduced virulence, mechanism(s) by which this occurs remain unknown. Here, we demonstrate a role for TF in antagonizing the host interferon response. Using wild-type and type 1 interferon receptor-deficient mice and primary cell...

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Literature Corpus work: 8f3c794a-ddef-5ce9-9b44-8a522d50074a
DOI: 10.1101/2019.12.13.875781

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