Article

The alphavirus TF protein plays a critical role in promoting viral propagation by altering cell-cell boundaries

2023-07-24

Abstract excerpt

During cellular infections, alphaviruses produce a 6 kDa membrane protein (6K) and a transframe variant (TF) of 6K through ribosomal frameshifting. The role of these proteins in alphavirus biology is largely unknown. Here, we show that TF of Chikungunya virus plays a unique and critical role in promoting virus propagation by manipulating host cell boundaries. TF achieves this by targeting and downregulating human...

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Identifiers and source

Literature Corpus work: 760aa6df-26d1-510e-a6e8-02b18bf81641
DOI: 10.1101/2023.07.24.550336

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