IFN-inducible Human Phospholipid Scramblase 1 (PLSCR1) Protein Restricts HIV-1 Infection by Inhibiting Membrane Fusion

Abstract excerpt

<h4>ABSTRACT</h4> Human phospholipid scramblase 1 (PLSCR1) is an interferon-stimulated gene (ISG) that inhibits viral infections through various mechanisms. Here, we identify PLSCR1 as a host restriction factor that inhibits HIV-1 entry by impairing membrane fusion mediated by the envelope glycoprotein (Env). Using multiple cell types including the human SupT1 T cell line and purified CD4 + T cells, we demonstra...

Topics

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• Cell Adhesion Molecules Research
• HIV/AIDS drug development and treatment
• HIV Research and Treatment
• interferon and immune responses
• RNA Research and Splicing
• Viral Infections and Immunology Research
• Viral Infectious Diseases and Gene Expression in Insects
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

f3116aeb-ddc1-5fa5-aecc-19bc353b43a2

DOI

10.1101/2025.06.23.661195