Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Interferon-Stimulated Gene Ifitm3 Restricts West Nile Virus Infection and Pathogenesis.

Journal of virology - 15 Sept 2016

Gorman Matthew J, Poddar Subhajit, Farzan Michael, Diamond Michael S

Abstract excerpt

UNLABELLED: The interferon-induced transmembrane protein (IFITM) family of proteins inhibit infection of several different enveloped viruses in cell culture by virtue of their ability to restrict entry and fusion from late endosomes. As few studies have evaluated the importance of Ifitm3 in vivo in restricting viral pathogenesis, we investigated its significance as an antiviral gene against West Nile virus (WNV),...

Topics

Join the communities discussing this publication.

Animal Structures
B-Lymphocytes
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Immunity, Innate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

West Nile Fever

West Nile virus

Source

Open in PubMed Open full text

Identifiers

PMID: 27384652
DOI: 10.1128/JVI.00581-16
PMCID: PMC5008082

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Interferon-Stimulated Gene Ifitm3 Restricts West Nile Virus Infection and Pathogenesis.PMID 27384652Read ↗

The Interferon-Stimulated Gene IFITM3 Restricts Infection and Pathogenesis of Arthritogenic and Encephalitic AlphavirusesSemantic proximity Read ↗

Antiviral Protection by IFITM3 In VivoSemantic proximity Read ↗

IFITM-Family Proteins: The Cell's First Line of Antiviral DefenseSemantic proximity Read ↗

IFITM3 Inhibits Influenza A Virus Infection by Preventing Cytosolic EntrySemantic proximity Read ↗

Ifitm3 limits the severity of acute influenza in mice.Semantic proximity Read ↗

Cell-specific IRF-3 responses protect against West Nile virus infection by interferon-dependent and -independent mechanisms.Semantic proximity Read ↗

Interferon-inducible Transmembrane Protein 3 (IFITM3) Restricts Reovirus Cell EntrySemantic proximity Read ↗

More than meets the I: the diverse antiviral and cellular functions of interferon-induced transmembrane proteinsSemantic proximity Read ↗

IFITM3-containing exosome as a novel mediator for anti-viral response in dengue virus infectionSemantic proximity Read ↗

IFITM proteins: Understanding their diverse roles in viral infection, cancer, and immunitySemantic proximity Read ↗

Opposing activities of IFITM proteins in SARS-CoV-2 infection.Semantic proximity Read ↗

The Host Response to West Nile Virus Infection Limits Viral Spread through the Activation of the Interferon Regulatory Factor 3 PathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.