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Article

TF protein of Sindbis virus antagonizes host type I interferon responses in a palmitoylation-dependent manner.

Virology - 1 Mar 2020

Rogers K J, Jones-Burrage S, Maury W, Mukhopadhyay S

Abstract excerpt

Sindbis virus (SINV) produces the small membrane protein TF from the 6K gene via a (-1) programmed ribosomal frameshifting. While several groups have shown that TF-deficient virus exhibits reduced virulence, the mechanism(s) by which this occurs remain unknown. Here, we demonstrate a role for TF in antagonizing the host interferon response. Using wild-type and type 1 interferon receptor-deficient mice and primary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32056669
DOI: 10.1016/j.virol.2020.01.001
PMCID: PMC7024065

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