Article

Productive Mayaro Virus Infection Requires Host Fatty Acid Synthase for nsP1 S-palmitoylation

2026-07-26

Abstract excerpt

To date, twenty-seven pathogenic human viruses require host-catalyzed de novo fatty acid biosynthesis for replication. This pathway is driven by fatty acid synthase (FASN), which produces palmitate. Palmitate is a precursor for various functions during viral infection, including lipid droplet formation for assembly, beta-oxidation for ATP generation, and post-translational modification of proteins. Whether Mayaro...

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Literature Corpus work: c460ec72-c430-53db-8e0b-97d2fafee103
DOI: 10.64898/2026.07.24.740668

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