Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of Palmitoylation of Replicase Protein nsP1 on Alphavirus Infection

1 Aug 2000

Abstract excerpt

The membrane-associated alphavirus RNA replication complex contains four virus-encoded subunits, the nonstructural proteins nsP1 to nsP4. Semliki Forest virus (SFV) nsP1 is hydrophobically modified by palmitoylation of cysteines 418 to 420. Here we show that Sindbis virus nsP1 is also palmitoylated on the same site (cysteine 420). When mutations preventing nsP1 palmitoylation were introduced into the genomes of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HIV Research and Treatment
Share to Mosquito-borne diseases and control
Share to Viral Infections and Outbreaks Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10888610
DOI: 10.1128/jvi.74.15.6725-6733.2000

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of Palmitoylation of Replicase Protein nsP1 on Alphavirus InfectionPMID 10888610Read ↗

Mutations at the palmitoylation site of non-structural protein nsP1 of Semliki Forest virus attenuate virus replication and cause accumulation of compensatory mutations.Semantic proximity Read ↗

The infection of mammalian and insect cells with SFV bearing nsP1 palmitoylation mutationsSemantic proximity Read ↗

Palmitoylation of Sindbis Virus TF Protein Regulates Its Plasma Membrane Localization and Subsequent Incorporation into Virions.Semantic proximity Read ↗

Palmitoylated Cysteines in Chikungunya Virus nsP1 Are Critical for Targeting to Cholesterol-Rich Plasma Membrane Microdomains with Functional Consequences for Viral Genome ReplicationSemantic proximity Read ↗

Palmitoylation of SARS-CoV-2 Envelope protein is central to virus particle formation.Semantic proximity Read ↗

Productive Mayaro Virus Infection Requires Host Fatty Acid Synthase for nsP1 S-palmitoylationSemantic proximity Read ↗

Effects of site-directed mutations of transmembrane cysteines in sindbis virus E1 and E2 glycoproteins on palmitylation and virus replication.Semantic proximity Read ↗

Palmitoylation at Residue C221 of Japanese Encephalitis Virus NS2A Protein Contributes to Viral Replication Efficiency and VirulenceSemantic proximity Read ↗

Effect of host cell lipid metabolism on alphavirus replication, virion morphogenesis, and infectivitySemantic proximity Read ↗

Semliki Forest virus mRNA capping enzyme requires association with anionic membrane phospholipids for activity.Semantic proximity Read ↗

Palmitoylation of the Influenza A Virus M2 Protein Is Not Required for Virus Replication In Vitro but Contributes to Virus VirulenceSemantic proximity Read ↗

Effects of mutagenesis of murine hepatitis virus nsp1 and nsp14 on replication in culture.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.