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Discovery of frameshifting in Alphavirus 6K resolves a 20-year enigma

1 Jan 2008

Abstract excerpt

BACKGROUND: The genus Alphavirus includes several potentially lethal human viruses. Additionally, species such as Sindbis virus and Semliki Forest virus are important vectors for gene therapy, vaccination and cancer research, and important models for virion assembly and structural analyses. The genome encodes nine known proteins, including the small '6K' protein. 6K appears to be involved in envelope protein...

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PMID: 18822126
DOI: 10.1186/1743-422x-5-108

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Discovery of frameshifting in Alphavirus 6K resolves a 20-year enigmaPMID 18822126Read ↗

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