Article
Mutation of the TYTLE motif in the cytoplasmic tail of the sendai virus fusion protein deeply affects viral assembly and particle production.
PloS one - 1 Jan 2013
Essaidi-Laziosi Manel, Shevtsova Anastasia, Gerlier Denis, Roux Laurent
Abstract excerpt
Enveloped viruses contain glycoproteins protruding from the viral membrane. These proteins play a crucial role in the extra-cellular steps of the virus life cycle, namely attachment to and entry into cells. Their role during the intracellular late phase of virus multiplication has been less appreciated, overlooked by the documented central organizer role of the matrix M protein. Sendai virus, a member of the...
Topics
- Amino Acid Motifs
- Amino Acid Substitution
- Animals
- Base Sequence
- Cell Membrane
- Cytoplasm
- DNA, Recombinant
- Dogs
- Madin Darby Canine Kidney Cells
- Molecular Imaging
- Mutation
