Structural analyses of the nucleosome complexes with human testis-specific histone variants, hTh2a and hTh2b.

doi:10.1016/j.bpc.2016.11.013

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Structural analyses of the nucleosome complexes with human testis-specific histone variants, hTh2a and hTh2b.

Biophysical chemistry - 1 Feb 2017

Padavattan Sivaraman, Thiruselvam Viswanathan, Shinagawa Toshie, Hasegawa Kazuya, Kumasaka Takashi, Ishii Shunsuke, Kumarevel Thirumananseri

Abstract excerpt

Th2a and Th2b are the testis-specific histone variants highly expressed during spermatogenesis. Approximately 4% of the genome is retained in nucleosomes in mature human sperm, which is enriched at loci of developmental importance. Our recent studies revealed that the mouse histone variant homologs TH2a and TH2b are involved in reprogramming. In the present work, we report three nucleosome structures (NCPs) with...

Topics

Chromatin
Chromatin Assembly and Disassembly
Crystallization
DNA
Gene Expression Regulation
Genetic Variation
Histones
Humans
Hydrogen Bonding
Male
Nucleosomes

Source

Open in PubMed

Identifiers

PMID: 27992841
DOI: 10.1016/j.bpc.2016.11.013

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics