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Article

Molecular mechanism of histone variant H2A.B on stability and assembly of nucleosome and chromatin structures.

Epigenetics & chromatin - 14 Jul 2020

Peng Junhui, Yuan Chuang, Hua Xinfan, Zhang Zhiyong

Abstract excerpt

BACKGROUND: H2A.B, the most divergent histone variant of H2A, can significantly modulate nucleosome and chromatin structures. However, the related structural details and the underlying mechanism remain elusive to date. In this work, we built atomic models of the H2A.B-containing nucleosome core particle (NCP), chromatosome, and chromatin fiber. Multiscale modeling including all-atom molecular dynamics and...

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Identifiers

PMID: 32664941
DOI: 10.1186/s13072-020-00351-x
PMCID: PMC7362417

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