Article

Mosaic chromosomal aneuploidy detection by sequencing (MAD-seq)

2017-05-25

Abstract excerpt

<h4>ABSTRACT</h4> Current approaches to detect and characterize mosaic chromosomal aneuploidy are limited by sensitivity, efficiency, cost or the need to culture cells. We describe a combination of a new sequencing-based assay and a novel analytical approach that allows low levels of mosaicism for chromosomal aneuploidy to be detected, assigned to a meiotic or mitotic origin, and quantified as a proportion of the...

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Literature Corpus work: 4706e95d-0ae5-537b-8791-c222cda2b34f
DOI: 10.1101/142299

Open publication

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