Article

Patterns and drivers of 43,617 mosaic chromosomal alterations in blood

2025-07-30

Abstract excerpt

Clonal expansions of hematopoietic cells carrying mosaic chromosomal alterations (mCAs) are commonly detectable in elderly individuals. Here, we studied 43,617 autosomal mCAs that we ascertained in 484,081 UK Biobank participants using new, high-resolution computational methods to analyze blood-derived whole-genome sequencing data. Shorter mCAs (≤1 Mb) clustered at 53 genomic hotspots (34 previously undetected), s...

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Literature Corpus work: c3e1a07d-6f2c-5e32-826c-f150741fa59b
DOI: 10.1101/2025.07.30.25332451

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