Article
Genetic predisposition to mosaic Y chromosome loss in blood.
Nature - 1 Nov 2019
Thompson Deborah J, Genovese Giulio, Halvardson Jonatan, Ulirsch Jacob C, Wright Daniel J, Terao Chikashi, Davidsson Olafur B, Day Felix R, Sulem Patrick, Jiang Yunxuan, Danielsson Marcus, Davies Hanna, Dennis Joe, Dunlop Malcolm G, Easton Douglas F, Fisher Victoria A, Zink Florian, Houlston Richard S, Ingelsson Martin, Kar Siddhartha, Kerrison Nicola D, Kinnersley Ben, Kristjansson Ragnar P, Law Philip J, Li Rong, Loveday Chey, Mattisson Jonas, McCarroll Steven A, Murakami Yoshinori, Murray Anna, Olszewski Pawel, Rychlicka-Buniowska Edyta, Scott Robert A, Thorsteinsdottir Unnur, Tomlinson Ian, Moghadam Behrooz Torabi, Turnbull Clare, Wareham Nicholas J, Gudbjartsson Daniel F, Kamatani Yoichiro, Hoffmann Eva R, Jackson Steve P, Stefansson Kari, Auton Adam, Ong Ken K, Machiela Mitchell J, Loh Po-Ru, Dumanski Jan P, Chanock Stephen J, Forsberg Lars A, Perry John R B
Abstract excerpt
Mosaic loss of chromosome Y (LOY) in circulating white blood cells is the most common form of clonal mosaicism1-5, yet our knowledge of the causes and consequences of this is limited. Here, using a computational approach, we estimate that 20% of the male population represented in the UK Biobank study (n = 205,011) has detectable LOY. We identify 156 autosomal genetic determinants of LOY, which we replicate in...
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