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Article

Patterns and drivers of 43,617 mosaic chromosomal alterations in blood.

Nature genetics - 1 Jun 2026

Tang David, Kamitaki Nolan, Mukamel Ronen E, Rubinacci Simone, Loh Po-Ru

Abstract excerpt

Clonal expansions of hematopoietic cells carrying mosaic chromosomal alterations (mCAs) are commonly detectable in elderly individuals. Here we studied 43,617 autosomal mCAs ascertained in 484,081 UK Biobank participants using new, high-resolution computational methods to analyze blood-derived, whole-genome sequencing data. Shorter mCAs (≤1 Mb) clustered at 53 genomic hotspots (46 previously undetected), several...

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Identifiers

PMID: 42156563
DOI: 10.1038/s41588-026-02592-0
PMCID: PMC13263154

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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