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Article

The evolution and mechanism of GPCR proton sensing.

The Journal of biological chemistry - 1 Jan 2000

Rowe Jacob B, Kapolka Nicholas J, Taghon Geoffrey J, Morgan William M, Isom Daniel G

Abstract excerpt

Of the 800 G protein-coupled receptors (GPCRs) in humans, only three (GPR4, GPR65, and GPR68) regulate signaling in acidified microenvironments by sensing protons (H+). How these receptors have uniquely obtained this ability is unknown. Here, we show these receptors evolved the capability to sense H+ signals by acquiring buried acidic residues. Using our informatics platform pHinder, we identified a triad of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33478938
DOI: 10.1074/jbc.RA120.016352
PMCID: PMC7948426

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