Article

Modulating proton sensing by the adenosine receptor A2

2026-05-29

Abstract excerpt

For years, it was believed that G-protein-coupled receptors (GPCRs) activated or modulated by changes in physiological pH were mechanistically regulated by pH-sensitive histidine residues on the receptor’s exterior. More recent studies have shown that traditional acid-sensing GPCRs (GPR4, GPR65, GPR68) contain buried acidic amino acids in their 7-transmembrane regions and can be activated by pH-dependent mechanism...

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Literature Corpus work: 09a3d43c-6f9a-56a6-9d47-c53024672c48
DOI: 10.64898/2026.05.26.727808

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